Title : Effect of pravastatin sodium, a new inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase, on very-low-density lipoprotein composition and kinetics in hyperlipidemia associated with experimental nephrosis.

Pub. Date : 1990 Jun

PMID : 2112675






3 Functional Relationships(s)
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1 Nephrotic rats, induced by a single intraperitoneal injection of puromycin aminonucleoside (100 mg/kg body weight), had significantly higher plasma lipids and apoprotein (apo) B concentrations than controls. Puromycin Aminonucleoside apolipoprotein B Rattus norvegicus
2 TG, cholesterol, phospholipid, and apo B concentrations in nephrotic VLDL were significantly reduced by Pravastatin treatment, whereas only TG was decreased in control VLDL. Pravastatin apolipoprotein B Rattus norvegicus
3 Pravastatin reduced the apo B 100 + 95/48 ratio in nephrotic VLDL. Pravastatin apolipoprotein B Rattus norvegicus