Title : CP-690,550, a therapeutic agent, inhibits cytokine-mediated Jak3 activation and proliferation of T cells from patients with ATL and HAM/TSP.

Pub. Date : 2011 Feb 10

PMID : 21106989






1 Functional Relationships(s)
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1 Finally, in an in vivo test of biological activity, CP-690,550 treatment of mice with a CD8 T-cell IL-15-transgenic leukemia that manifests an autocrine IL-15/IL-15Ralpha pathway prolonged the survival duration of these tumor-bearing mice. tofacitinib interleukin 15 receptor, alpha chain Mus musculus