Title : Noncytotoxic inhibition of cytomegalovirus replication through NK cell protease granzyme M-mediated cleavage of viral phosphoprotein 71.

Pub. Date : 2010 Dec 15

PMID : 21059895






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 GrM directly cleaved pp71 after Leu(439), which coincided with aberrant cellular localization of both pp71 cleavage fragments as determined by confocal immunofluorescence. Leucine granzyme M Homo sapiens
2 In a luciferase reporter assay, cleavage of pp71 after Leu(439) by GrM completely abolished the ability of pp71 to transactivate the HCMV major immediate-early promoter, which is indispensable for effective HCMV replication. Leucine granzyme M Homo sapiens