Pub. Date : 2010 Nov 5
PMID : 20933505
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | To better understand how EWS-Fli1 affects FOXO1 expression, we have established a doxycycline-inducible siRNA system to achieve stable and reversible knockdown of EWS-Fli1 in Ewing"s sarcoma cells. | Doxycycline | EWS RNA binding protein 1 | Homo sapiens |
| 2 | To better understand how EWS-Fli1 affects FOXO1 expression, we have established a doxycycline-inducible siRNA system to achieve stable and reversible knockdown of EWS-Fli1 in Ewing"s sarcoma cells. | Doxycycline | EWS RNA binding protein 1 | Homo sapiens |
| 3 | Here we show that FOXO1 expression in Ewing"s cells has an inverse relationship with EWS-Fli1 protein level, and FOXO1 promoter activity is increased after doxycycline-induced EWS-Fli1 knockdown. | Doxycycline | EWS RNA binding protein 1 | Homo sapiens |
| 4 | In addition, we have found that direct binding of EWS-Fli1 to FOXO1 promoter is attenuated after doxycycline-induced siRNA knockdown of the fusion protein. | Doxycycline | EWS RNA binding protein 1 | Homo sapiens |