Title : The β-blocker atenolol lowers the longevity-related degree of fatty acid unsaturation, decreases protein oxidative damage, and increases extracellular signal-regulated kinase signaling in the heart of C57BL/6 mice.

Pub. Date : 2010 Dec

PMID : 20818929






1 Functional Relationships(s)
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1 These results support the idea that the increased longevity of the AC5 KO mice can be due in part to an ERK signaling-mediated stress-resistance due to a decrease in fatty acid unsaturation, leading to lower lipid peroxidation and decreased lipoxidation-derived damage to cellular proteins. Fatty Acids adenylate cyclase 5 Mus musculus