Title : Negative regulation of globin gene expression during megakaryocytic differentiation of a human erythroleukemic cell line.

Pub. Date : 1991 Jul

PMID : 2046667






1 Functional Relationships(s)
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1 K562 cells normally synthesize fetal hemoglobin (gamma-globin), but treatment with tumor-promoting phorbol esters (phorbol myristate acetate and tetradecanoyl phorbol acetate) results in the loss of the erythroid phenotype of the cells and causes a shift toward a megakaryocytic phenotype. Phorbol Esters hemoglobin subunit gamma 1 Homo sapiens