Title : Activation by tyrosine phosphorylation as a prerequisite for protein kinase Cζ to mediate epidermal growth factor receptor signaling to ERK.

Pub. Date : 2010 May

PMID : 20407013






8 Functional Relationships(s)
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1 Activation by tyrosine phosphorylation as a prerequisite for protein kinase Czeta to mediate epidermal growth factor receptor signaling to ERK. Tyrosine protein kinase C, zeta Mus musculus
2 Here, it is shown that EGF may induce tyrosine phosphorylation of PKCzeta in several HNSCC cells, breast carcinoma cells, as well as mouse embryonic fibroblasts. Tyrosine protein kinase C, zeta Mus musculus
3 In COS-7 cells overexpressing EGF receptor (EGFR) and PKCzeta as a tumor cell model, we show that PKCzeta tyrosine phosphorylation by EGF is induced by catalytic activation. Tyrosine protein kinase C, zeta Mus musculus
4 In COS-7 cells overexpressing EGF receptor (EGFR) and PKCzeta as a tumor cell model, we show that PKCzeta tyrosine phosphorylation by EGF is induced by catalytic activation. Tyrosine protein kinase C, zeta Mus musculus
5 Using a loss-of-function mutant of PKCzeta, we can show that the tyrosine residue 417 in PKCzeta plays an important role in both PKCzeta activation and the ability of PKCzeta to mediate activation of ERK. Tyrosine protein kinase C, zeta Mus musculus
6 Using a loss-of-function mutant of PKCzeta, we can show that the tyrosine residue 417 in PKCzeta plays an important role in both PKCzeta activation and the ability of PKCzeta to mediate activation of ERK. Tyrosine protein kinase C, zeta Mus musculus
7 Using a loss-of-function mutant of PKCzeta, we can show that the tyrosine residue 417 in PKCzeta plays an important role in both PKCzeta activation and the ability of PKCzeta to mediate activation of ERK. Tyrosine protein kinase C, zeta Mus musculus
8 Using a loss-of-function mutant of PKCzeta, we can show that the tyrosine residue 417 in PKCzeta plays an important role in both PKCzeta activation and the ability of PKCzeta to mediate activation of ERK. Tyrosine protein kinase C, zeta Mus musculus