Title : Induction of differentiation in human myeloblastic leukemia ML-1 cells by heptachlor, a chlorinated hydrocarbon insecticide.

Pub. Date : 1991 Jun 1

PMID : 2038753






5 Functional Relationships(s)
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1 Induction of differentiation in human myeloblastic leukemia ML-1 cells by heptachlor, a chlorinated hydrocarbon insecticide. Heptachlor interleukin 17F Homo sapiens
2 Effects of heptachlor, an organochlorine pesticide, on human myeloblastic leukemia ML-1 cells were determined. Heptachlor interleukin 17F Homo sapiens
3 Similar to 12-O-tetradecanoylphorbol-13-acetate (TPA), a known tumor promoter, heptachlor induced cell adherence and formation of extended cytoplasmic pseudopodia in ML-1 cells. Heptachlor interleukin 17F Homo sapiens
4 The growth of ML-1 was slightly stimulated by low concentrations (less than 30 nM) of heptachlor. Heptachlor interleukin 17F Homo sapiens
5 A dose-responsive cell death was also observed when ML-1 cells were treated with heptachlor at concentrations greater than 80 microM. Heptachlor interleukin 17F Homo sapiens