Pub. Date : 1991 Jun 5
PMID : 2037582
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The integrity of the cysteine 186-cysteine 209 bond of the second disulfide loop of tissue factor is required for binding of factor VII. | Cysteine | coagulation factor III, tissue factor | Homo sapiens |
| 2 | The integrity of the cysteine 186-cysteine 209 bond of the second disulfide loop of tissue factor is required for binding of factor VII. | Cysteine | coagulation factor III, tissue factor | Homo sapiens |
| 3 | The integrity of the cysteine 186-cysteine 209 bond of the second disulfide loop of tissue factor is required for binding of factor VII. | Disulfides | coagulation factor III, tissue factor | Homo sapiens |
| 4 | The functional significance of the two disulfide bonded loops in the surface domain of TF has been analyzed using site-directed mutagenesis to selectively preclude covalent stabilization of these loops by pairwise substitution of serine residues for cysteines. | Disulfides | coagulation factor III, tissue factor | Homo sapiens |
| 5 | The functional significance of the two disulfide bonded loops in the surface domain of TF has been analyzed using site-directed mutagenesis to selectively preclude covalent stabilization of these loops by pairwise substitution of serine residues for cysteines. | Serine | coagulation factor III, tissue factor | Homo sapiens |
| 6 | The functional significance of the two disulfide bonded loops in the surface domain of TF has been analyzed using site-directed mutagenesis to selectively preclude covalent stabilization of these loops by pairwise substitution of serine residues for cysteines. | Cysteine | coagulation factor III, tissue factor | Homo sapiens |
| 7 | Mutant TF lacking either the amino (TFS49S57) or carboxyl (TFS186S209) disulfide bond were expressed on the surface of cells consistent with proper processing. | Disulfides | coagulation factor III, tissue factor | Homo sapiens |
| 8 | These data suggest that the Cys186-Cys209 disulfide bond is required to maintain conformation and implicate the disulfide loop or adjacent structures in the carboxyl half of the surface domain of TF in receptor function. | Disulfides | coagulation factor III, tissue factor | Homo sapiens |
| 9 | These data suggest that the Cys186-Cys209 disulfide bond is required to maintain conformation and implicate the disulfide loop or adjacent structures in the carboxyl half of the surface domain of TF in receptor function. | Disulfides | coagulation factor III, tissue factor | Homo sapiens |