Pub. Date : 1991 Apr 8
PMID : 2031249
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Relationship between covalent binding to microsomal protein and the destruction of adrenal cytochrome P-450 by spironolactone. | Spironolactone | cytochrome P450 3A14 | Cavia porcellus |
| 2 | Studies were done to evaluate the relationship between the destruction of cytochrome P-450 and the covalent binding to microsomal protein by SL and by 7 alpha-thiospironolactone (7 alpha-thio-SL), an obligatory intermediate in the activation pathway. | alpha-thiospironolactone | cytochrome P450 3A14 | Cavia porcellus |
| 3 | However, all of the data are consistent with the hypothesis that 7 alpha-thio-SL is a suicide inhibitor of adrenal cytochrome P-450 and that covalent binding to protein is involved in the degradation of cytochrome P-450. | 7 alpha-thiospironolactone | cytochrome P450 3A14 | Cavia porcellus |