Title : Direct fibrogenic effects of aldosterone on normotensive kidney: an effect modified by 11β-HSD activity.

Pub. Date : 2010 May

PMID : 20200098






6 Functional Relationships(s)
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1 In contrast, IMCD treated with Aldo exhibited a marked increase in the expression of collagen, fibronectin, and connective tissue growth factor (CTGF), whereas corticosterone alone had no effect. imcd cellular communication network factor 2 Mus musculus
2 In contrast, IMCD treated with Aldo exhibited a marked increase in the expression of collagen, fibronectin, and connective tissue growth factor (CTGF), whereas corticosterone alone had no effect. imcd cellular communication network factor 2 Mus musculus
3 In contrast, IMCD treated with Aldo exhibited a marked increase in the expression of collagen, fibronectin, and connective tissue growth factor (CTGF), whereas corticosterone alone had no effect. Aldosterone cellular communication network factor 2 Mus musculus
4 In contrast, IMCD treated with Aldo exhibited a marked increase in the expression of collagen, fibronectin, and connective tissue growth factor (CTGF), whereas corticosterone alone had no effect. Aldosterone cellular communication network factor 2 Mus musculus
5 The Aldo-induced overexperession of collagen, fibronectin, and CTGF was substantially attenuated by the MR antagonist RU-318 and by the 11beta-HSD end product 11-dehydrocorticosterone, but not by the glucocorticoid receptor antagonist RU-486. ru-318 cellular communication network factor 2 Mus musculus
6 In vivo, early fibrotic changes with elevated collagen, fibronectin, and CTGF expression were observed in kidneys isolated from normotensive adrenalectomized mice receiving a continuous infusion of Aldo (8 mug kg(-1) day(-1)) for 1 wk. Aldosterone cellular communication network factor 2 Mus musculus