Title : p53 Regulates the Ras circuit to inhibit the expression of a cancer-related gene signature by various molecular pathways.

Pub. Date : 2010 Mar 15

PMID : 20197462






1 Functional Relationships(s)
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1 Whereas BTG2 binds H-Ras(G12V) and represses its activity by reducing its GTP loading state, which in turn causes a reduction in CGS expression, ATF3 binds directly to the CGS promoters following p53 stabilization and represses their expression. Guanosine Triphosphate BTG anti-proliferation factor 2 Homo sapiens