Pub. Date : 2010 May 15
PMID : 20171238
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | OATP-mediated uptake of MC congeners MCLR, -RR, -LW and -LF was compared in primary human hepatocytes and HEK293 cells stably expressing recombinant human OATP1B1/SLCO1B1 and OATP1B3/SLCO1B3 in the presence/absence of OATP substrates taurocholate (TC) and bromosulfophthalein (BSP) and measuring PP-inhibition and cytotoxicity. | microcystin | solute carrier organic anion transporter family member 1A2 | Homo sapiens |
2 | Control vector expressing HEK293 were resistant to MC cytotoxicity, while TC and BSP competition experiments reduced MC cytotoxicity in HEK293-OATP transfectants, thus confirming the requirement of OATPs for trans-membrane transport. | microcystin | solute carrier organic anion transporter family member 1A2 | Homo sapiens |