Pub. Date : 2010 Mar 1
PMID : 20160506
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Recent work has revealed that two DNA damage response proteins, the Tip60 acetyltransferase and the mre11- rad50-nbs1 (MRN) complex, co-operate in the activation of ATM in response to DSBs. | 1,2-di-(4-sulfamidophenyl)-4-butylpyrazolidine-3,5-dione | lysine acetyltransferase 5 | Homo sapiens |
| 2 | MRN functions to target ATM and the Tip60 acetyltransferase to DSBs. | 1,2-di-(4-sulfamidophenyl)-4-butylpyrazolidine-3,5-dione | lysine acetyltransferase 5 | Homo sapiens |
| 3 | Tip60"s chromodomain then interacts with histone H3 trimethylated on lysine 9, activating Tip60"s acetyltransferase activity and stimulating the subsequent acetylation and activation of ATM"s kinase activity. | Lysine | lysine acetyltransferase 5 | Homo sapiens |
| 4 | Tip60"s chromodomain then interacts with histone H3 trimethylated on lysine 9, activating Tip60"s acetyltransferase activity and stimulating the subsequent acetylation and activation of ATM"s kinase activity. | Lysine | lysine acetyltransferase 5 | Homo sapiens |