Title : Na/H exchange inhibition protects newborn heart from ischemia/reperfusion injury by limiting Na+-dependent Ca2+ overload.

Pub. Date : 2010 Mar

PMID : 20010437






2 Functional Relationships(s)
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1 This is because overwhelming evidence is consistent with the hypothesis that myocardial ischemic injury results in part from increases in intracellular Na (Nai) mediated by NHE1 that in turn promote Na/Ca exchanger-mediated increases in intracellular Ca ([Ca]i) and Ca-dependent cell damage. Sodium Iodide sodium/hydrogen exchanger 1 Oryctolagus cuniculus
2 In conclusion, NHE1 inhibition diminishes ischemia-induced increases in Nai and therefore [Ca], and thus diminishes myocardial injury in neonatal hearts. Sodium Iodide sodium/hydrogen exchanger 1 Oryctolagus cuniculus