Title : Interactions between steroid hormones and insulin-like growth factor-I in rabbit chondrocytes.

Pub. Date : 1991 Mar

PMID : 1999163






15 Functional Relationships(s)
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1 In contrast, when confluent cultures were incubated with one of the sex steroids for 24 h before the addition of IGF-I, stimulation of DNA synthesis by the growth factor was enhanced about 45% above the control value by 0.5 nM progesterone, 50% by 0.5 nM testosterone, and 80% by 50 nM 17 beta-estradiol. Steroids insulin-like growth factor I Oryctolagus cuniculus
2 In contrast, when confluent cultures were incubated with one of the sex steroids for 24 h before the addition of IGF-I, stimulation of DNA synthesis by the growth factor was enhanced about 45% above the control value by 0.5 nM progesterone, 50% by 0.5 nM testosterone, and 80% by 50 nM 17 beta-estradiol. Progesterone insulin-like growth factor I Oryctolagus cuniculus
3 In contrast, when confluent cultures were incubated with one of the sex steroids for 24 h before the addition of IGF-I, stimulation of DNA synthesis by the growth factor was enhanced about 45% above the control value by 0.5 nM progesterone, 50% by 0.5 nM testosterone, and 80% by 50 nM 17 beta-estradiol. Testosterone insulin-like growth factor I Oryctolagus cuniculus
4 In contrast, when confluent cultures were incubated with one of the sex steroids for 24 h before the addition of IGF-I, stimulation of DNA synthesis by the growth factor was enhanced about 45% above the control value by 0.5 nM progesterone, 50% by 0.5 nM testosterone, and 80% by 50 nM 17 beta-estradiol. Estradiol insulin-like growth factor I Oryctolagus cuniculus
5 The effects of IGF-I on proteoglycan synthesis, as judged by the incorporation of [35S]sulfate, were stimulated by treatment with progesterone or testosterone. Sulfur-35 insulin-like growth factor I Oryctolagus cuniculus
6 The effects of IGF-I on proteoglycan synthesis, as judged by the incorporation of [35S]sulfate, were stimulated by treatment with progesterone or testosterone. Sulfates insulin-like growth factor I Oryctolagus cuniculus
7 The effects of IGF-I on proteoglycan synthesis, as judged by the incorporation of [35S]sulfate, were stimulated by treatment with progesterone or testosterone. Progesterone insulin-like growth factor I Oryctolagus cuniculus
8 The effects of IGF-I on proteoglycan synthesis, as judged by the incorporation of [35S]sulfate, were stimulated by treatment with progesterone or testosterone. Testosterone insulin-like growth factor I Oryctolagus cuniculus
9 At 50 nM, dexamethasone suppressed IGF-I induction of DNA synthesis by 60%. Dexamethasone insulin-like growth factor I Oryctolagus cuniculus
10 This suppression was greater when dexamethasone was added before IGF-I than when the additions were simultaneous. Dexamethasone insulin-like growth factor I Oryctolagus cuniculus
11 When chondrocytes were treated with hydrocortisone or dexamethasone for 24 h before the addition of IGF-I, the glucocorticoids synergistically accelerated proteoglycan synthesis mediated by IGF-I. Hydrocortisone insulin-like growth factor I Oryctolagus cuniculus
12 When chondrocytes were treated with hydrocortisone or dexamethasone for 24 h before the addition of IGF-I, the glucocorticoids synergistically accelerated proteoglycan synthesis mediated by IGF-I. Hydrocortisone insulin-like growth factor I Oryctolagus cuniculus
13 When chondrocytes were treated with hydrocortisone or dexamethasone for 24 h before the addition of IGF-I, the glucocorticoids synergistically accelerated proteoglycan synthesis mediated by IGF-I. Dexamethasone insulin-like growth factor I Oryctolagus cuniculus
14 When chondrocytes were treated with hydrocortisone or dexamethasone for 24 h before the addition of IGF-I, the glucocorticoids synergistically accelerated proteoglycan synthesis mediated by IGF-I. Dexamethasone insulin-like growth factor I Oryctolagus cuniculus
15 These findings suggest that steroid hormones have priming effects on the biological action of IGF-I in cartilage metabolism. Steroids insulin-like growth factor I Oryctolagus cuniculus