Title : Carbonic anhydrase inhibitors. Identification of selective inhibitors of the human mitochondrial isozymes VA and VB over the cytosolic isozymes I and II from a natural product-based phenolic library.

Pub. Date : 2010 Jan 1

PMID : 19962903






1 Functional Relationships(s)
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1 The selectivity ratios for inhibiting the mitochondrial over the cytosolic isoforms for these phenol derivatives were in the range of 120-3800, making them the most isoform-selective compounds for inhibiting hCA VA/VB known to date. Phenol carbonic anhydrase 5A Homo sapiens