Pub. Date : 2009 Oct
PMID : 19947172
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Fluorofenidone inhibits TGF-beta1 induced CTGF via MAPK pathways in mouse mesangial cells. | 5-methyl-1-(3-fluorophenyl)-2-(1H)-pyridone | cellular communication network factor 2 | Mus musculus |
| 2 | The present study was designed to investigate the potential mechanism of fluorofenidone involving the downregulation of CTGF expression induced by TGF-beta1 and the related signaling pathway in mouse mesangial cells (MMCs). | 5-methyl-1-(3-fluorophenyl)-2-(1H)-pyridone | cellular communication network factor 2 | Mus musculus |
| 3 | Fluorofenidone, PD98059 and SB203580 could partially inhibit TGF-beta1-induced expression of CTGF in mouse mesangial cells, however, JNK inhibitor II had no effect. | 5-methyl-1-(3-fluorophenyl)-2-(1H)-pyridone | cellular communication network factor 2 | Mus musculus |
| 4 | Fluorofenidone, PD98059 and SB203580 could partially inhibit TGF-beta1-induced expression of CTGF in mouse mesangial cells, however, JNK inhibitor II had no effect. | 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one | cellular communication network factor 2 | Mus musculus |
| 5 | Fluorofenidone, PD98059 and SB203580 could partially inhibit TGF-beta1-induced expression of CTGF in mouse mesangial cells, however, JNK inhibitor II had no effect. | SB 203580 | cellular communication network factor 2 | Mus musculus |
| 6 | CONCLUSIONS: The antifibrotic effects of fluorofenidone are suggested to be mediated byits actions through inhibition of MAPK activation and consequent reduction of CTGF expression. | 5-methyl-1-(3-fluorophenyl)-2-(1H)-pyridone | cellular communication network factor 2 | Mus musculus |