Pub. Date : 2011 Feb
PMID : 19929948
9 Functional Relationships(s)Download |
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Sentence | Compound Name | Protein Name | Organism |
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| 1 | Role for LAMP-2 in endosomal cholesterol transport. | Cholesterol | lysosomal associated membrane protein 2 | Homo sapiens | ||
| 2 | We showed previously that unesterified cholesterol accumulates in the late endosomes and lysosomes of fibroblasts deficient in both lysosome associated membrane protein-2 (LAMP-2) and LAMP-1, two abundant membrane proteins of late endosomes and lysosomes. | Cholesterol | lysosomal associated membrane protein 2 | Homo sapiens | ||
| 3 | We showed previously that unesterified cholesterol accumulates in the late endosomes and lysosomes of fibroblasts deficient in both lysosome associated membrane protein-2 (LAMP-2) and LAMP-1, two abundant membrane proteins of late endosomes and lysosomes. | Cholesterol | lysosomal associated membrane protein 2 | Homo sapiens | ||
| 4 | We also show that cholesterol accumulates in LAMP-2 deficient liver and that overexpression of LAMP-2 retards the lysosomal cholesterol accumulation induced by U18666A. | Cholesterol | lysosomal associated membrane protein 2 | Homo sapiens | ||
| 5 | We also show that cholesterol accumulates in LAMP-2 deficient liver and that overexpression of LAMP-2 retards the lysosomal cholesterol accumulation induced by U18666A. | Cholesterol | lysosomal associated membrane protein 2 | Homo sapiens | ||
| 6 | We also show that cholesterol accumulates in LAMP-2 deficient liver and that overexpression of LAMP-2 retards the lysosomal cholesterol accumulation induced by U18666A. | Cholesterol | lysosomal associated membrane protein 2 | Homo sapiens | ||
| 7 | These results point to a critical role for LAMP-2 in endosomal/lysosomal cholesterol export. | Cholesterol | lysosomal associated membrane protein 2 | Homo sapiens | ||
| 8 | Moreover, the late endosomal/lysosomal cholesterol accumulation in LAMP(-/-) cells was diminished by overexpression of any of the three isoforms of LAMP-2, but not by LAMP-1. | Cholesterol | lysosomal associated membrane protein 2 | Homo sapiens | ||
| 9 | Taken together, our results suggest that LAMP-2, its luminal domain in particular, plays a critical role in endosomal cholesterol transport and that this is distinct from the chaperone-mediated autophagy function of LAMP-2. | Cholesterol | lysosomal associated membrane protein 2 | Homo sapiens | ||