Pub. Date : 2009 Dec
PMID : 19922557
17 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We have recently demonstrated preferential inhibition of AC5 by lithium. | Lithium | adenylate cyclase 5 | Mus musculus |
| 2 | RESULTS: Carbamazepine preferentially inhibited forskolin-stimulated AC5 and AC1 and all D1 agonist-stimulated ACs, with AC5 and AC7 being the most sensitive. | Carbamazepine | adenylate cyclase 5 | Mus musculus |
| 3 | RESULTS: Carbamazepine preferentially inhibited forskolin-stimulated AC5 and AC1 and all D1 agonist-stimulated ACs, with AC5 and AC7 being the most sensitive. | Carbamazepine | adenylate cyclase 5 | Mus musculus |
| 4 | RESULTS: Carbamazepine preferentially inhibited forskolin-stimulated AC5 and AC1 and all D1 agonist-stimulated ACs, with AC5 and AC7 being the most sensitive. | Colforsin | adenylate cyclase 5 | Mus musculus |
| 5 | When compared to 1 or 3 mM Mg(2+), 10 mM Mg(2+) reduced lithium-induced AC5 inhibition by 70%. | magnesium ion | adenylate cyclase 5 | Mus musculus |
| 6 | When compared to 1 or 3 mM Mg(2+), 10 mM Mg(2+) reduced lithium-induced AC5 inhibition by 70%. | Lithium | adenylate cyclase 5 | Mus musculus |
| 7 | In silico modeling suggests that among AC isoforms carbamazepine preferentially affects AC1 and AC5 by interacting with the catechol-estrogen site. | Carbamazepine | adenylate cyclase 5 | Mus musculus |
| 8 | In silico modeling suggests that among AC isoforms carbamazepine preferentially affects AC1 and AC5 by interacting with the catechol-estrogen site. | catechol | adenylate cyclase 5 | Mus musculus |
| 9 | CONCLUSIONS: Lithium and carbamazepine preferentially inhibit AC5, albeit via different mechanisms. | Lithium | adenylate cyclase 5 | Mus musculus |
| 10 | CONCLUSIONS: Lithium and carbamazepine preferentially inhibit AC5, albeit via different mechanisms. | Carbamazepine | adenylate cyclase 5 | Mus musculus |
| 11 | Antidepressant-like behavior of AC5 knockout mice in the forced-swim test supports the notion that AC5 inhibition is involved in the antidepressant effect of lithium and carbamazepine. | Lithium | adenylate cyclase 5 | Mus musculus |
| 12 | Antidepressant-like behavior of AC5 knockout mice in the forced-swim test supports the notion that AC5 inhibition is involved in the antidepressant effect of lithium and carbamazepine. | Lithium | adenylate cyclase 5 | Mus musculus |
| 13 | Antidepressant-like behavior of AC5 knockout mice in the forced-swim test supports the notion that AC5 inhibition is involved in the antidepressant effect of lithium and carbamazepine. | Carbamazepine | adenylate cyclase 5 | Mus musculus |
| 14 | Antidepressant-like behavior of AC5 knockout mice in the forced-swim test supports the notion that AC5 inhibition is involved in the antidepressant effect of lithium and carbamazepine. | Carbamazepine | adenylate cyclase 5 | Mus musculus |
| 15 | The effect of lithium and carbamazepine to lower cAMP formation in AC5-rich dopaminergic brain regions suggests that D1-dopamine receptors in these regions are involved in the antidepressant effect of mood stabilizers. | Lithium | adenylate cyclase 5 | Mus musculus |
| 16 | The effect of lithium and carbamazepine to lower cAMP formation in AC5-rich dopaminergic brain regions suggests that D1-dopamine receptors in these regions are involved in the antidepressant effect of mood stabilizers. | Carbamazepine | adenylate cyclase 5 | Mus musculus |
| 17 | The effect of lithium and carbamazepine to lower cAMP formation in AC5-rich dopaminergic brain regions suggests that D1-dopamine receptors in these regions are involved in the antidepressant effect of mood stabilizers. | Cyclic AMP | adenylate cyclase 5 | Mus musculus |