Pub. Date : 2009 Oct 6
PMID : 19755121
10 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Activation of adenylate cyclase by forskolin increases the protein stability of RCAN1 (DSCR1 or Adapt78). | Colforsin | regulator of calcineurin 1 | Homo sapiens |
| 2 | Activation of adenylate cyclase by forskolin increases the protein stability of RCAN1 (DSCR1 or Adapt78). | Colforsin | regulator of calcineurin 1 | Homo sapiens |
| 3 | Activation of adenylate cyclase by forskolin increases the protein stability of RCAN1 (DSCR1 or Adapt78). | Colforsin | regulator of calcineurin 1 | Homo sapiens |
| 4 | In this report, we find that activation of adenylate cyclase by forskolin increases the expression of RCAN1 through the increase of the protein"s half-life. | Colforsin | regulator of calcineurin 1 | Homo sapiens |
| 5 | The ability of forskolin to increase the accumulation of RCAN1 protein is significantly inhibited with protein kinase A inhibitors such as KT5720 and H-89. | Colforsin | regulator of calcineurin 1 | Homo sapiens |
| 6 | The ability of forskolin to increase the accumulation of RCAN1 protein is significantly inhibited with protein kinase A inhibitors such as KT5720 and H-89. | KT 5720 | regulator of calcineurin 1 | Homo sapiens |
| 7 | The ability of forskolin to increase the accumulation of RCAN1 protein is significantly inhibited with protein kinase A inhibitors such as KT5720 and H-89. | N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide | regulator of calcineurin 1 | Homo sapiens |
| 8 | Furthermore, forskolin targets the central and C-terminal region of RCAN1 and enhances the inhibitory effect of RCAN1 on the calcineurin-mediated activation of NFAT. | Colforsin | regulator of calcineurin 1 | Homo sapiens |
| 9 | Furthermore, forskolin targets the central and C-terminal region of RCAN1 and enhances the inhibitory effect of RCAN1 on the calcineurin-mediated activation of NFAT. | Colforsin | regulator of calcineurin 1 | Homo sapiens |
| 10 | Our findings provide the first evidence that the accumulation of the RCAN1 protein by cAMP acts as an important regulatory mechanism in the control of the calcineurin-dependent cellular pathway. | Cyclic AMP | regulator of calcineurin 1 | Homo sapiens |