Title : Mapping the ligand-binding pocket of integrin alpha5beta1 using a gain-of-function approach.

Pub. Date : 2009 Nov 11

PMID : 19747169






2 Functional Relationships(s)
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1 Zebrafish alpha5beta1 integrins do bind zebrafish fibronectin-1, and mutagenesis of residues on the upper surface and side of the zebrafish alpha5 subunit beta-propeller domain shows that these residues are important for the recognition of the Arg-Gly-Asp (RGD) motif and the synergy sequence [Pro-His-Ser-Arg-Asn (PHSRN)] in fibronectin. L-Histidine, L-prolyl- fibronectin 1a Danio rerio
2 Zebrafish alpha5beta1 integrins do bind zebrafish fibronectin-1, and mutagenesis of residues on the upper surface and side of the zebrafish alpha5 subunit beta-propeller domain shows that these residues are important for the recognition of the Arg-Gly-Asp (RGD) motif and the synergy sequence [Pro-His-Ser-Arg-Asn (PHSRN)] in fibronectin. L-Histidine, L-prolyl- fibronectin 1a Danio rerio