Pub. Date : 2009 Sep 2
PMID : 19725972
10 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Studies reported here evaluated the differential regulation and function of the two transcripts and protein products of RCAN1 by the synthetic GC dexamethasone (Dex), and by modulators of calcium signaling. | Dexamethasone | regulator of calcineurin 1 | Homo sapiens |
| 2 | Studies reported here evaluated the differential regulation and function of the two transcripts and protein products of RCAN1 by the synthetic GC dexamethasone (Dex), and by modulators of calcium signaling. | Dexamethasone | regulator of calcineurin 1 | Homo sapiens |
| 3 | RESULTS: Dex selectively upregulates transcript specific for RCAN 1-1 in glucocorticoid (GC)-susceptible human leukemic CEM-C7-14 cells but not in GC-refractory CEM-C1-15 sister cells. | Dexamethasone | regulator of calcineurin 1 | Homo sapiens |
| 4 | Expression of the second major transcript, RCAN1-4, is upregulated by [Ca2+]i inducers, thapsigargin and A23187, but not by Dex, suggesting a mutually exclusive regulatory pathway for both RCAN1 transcripts. | Thapsigargin | regulator of calcineurin 1 | Homo sapiens |
| 5 | Expression of the second major transcript, RCAN1-4, is upregulated by [Ca2+]i inducers, thapsigargin and A23187, but not by Dex, suggesting a mutually exclusive regulatory pathway for both RCAN1 transcripts. | Thapsigargin | regulator of calcineurin 1 | Homo sapiens |
| 6 | Expression of the second major transcript, RCAN1-4, is upregulated by [Ca2+]i inducers, thapsigargin and A23187, but not by Dex, suggesting a mutually exclusive regulatory pathway for both RCAN1 transcripts. | Calcimycin | regulator of calcineurin 1 | Homo sapiens |
| 7 | Expression of the second major transcript, RCAN1-4, is upregulated by [Ca2+]i inducers, thapsigargin and A23187, but not by Dex, suggesting a mutually exclusive regulatory pathway for both RCAN1 transcripts. | Calcimycin | regulator of calcineurin 1 | Homo sapiens |
| 8 | Expression of the second major transcript, RCAN1-4, is upregulated by [Ca2+]i inducers, thapsigargin and A23187, but not by Dex, suggesting a mutually exclusive regulatory pathway for both RCAN1 transcripts. | Dexamethasone | regulator of calcineurin 1 | Homo sapiens |
| 9 | RCAN1-1 coimmunoprecipitates with calcineurin PP3C and Dex-mediated RCAN1-1 upregulation correlated with reduction in calcineurin PP3C activity. | Dexamethasone | regulator of calcineurin 1 | Homo sapiens |
| 10 | RCAN1-1 coimmunoprecipitates with calcineurin PP3C and Dex-mediated RCAN1-1 upregulation correlated with reduction in calcineurin PP3C activity. | Dexamethasone | regulator of calcineurin 1 | Homo sapiens |