Pub. Date : 1991
PMID : 1953354
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Prostaglandin H synthase dependent metabolism of diethylstilbestrol by ram seminal vesicle cell cultures. | Diethylstilbestrol | pterin-4 alpha-carbinolamine dehydratase 1 | Homo sapiens |
| 2 | Compounds expected to modulate PHS-dependent co-oxidation of DES increased (arachidonic acid) or inhibited (indomethacin) Z,Z-DIES formation of SEMV cells in culture. | Diethylstilbestrol | pterin-4 alpha-carbinolamine dehydratase 1 | Homo sapiens |
| 3 | Compounds expected to modulate PHS-dependent co-oxidation of DES increased (arachidonic acid) or inhibited (indomethacin) Z,Z-DIES formation of SEMV cells in culture. | Arachidonic Acid | pterin-4 alpha-carbinolamine dehydratase 1 | Homo sapiens |
| 4 | Compounds expected to modulate PHS-dependent co-oxidation of DES increased (arachidonic acid) or inhibited (indomethacin) Z,Z-DIES formation of SEMV cells in culture. | Indomethacin | pterin-4 alpha-carbinolamine dehydratase 1 | Homo sapiens |
| 5 | Compounds expected to modulate PHS-dependent co-oxidation of DES increased (arachidonic acid) or inhibited (indomethacin) Z,Z-DIES formation of SEMV cells in culture. | z-dies | pterin-4 alpha-carbinolamine dehydratase 1 | Homo sapiens |
| 6 | A comparison of rates of arachidonic acid turnover to prostaglandins on the one hand and DES oxidation on the other reveals that DES is oxidized despite the presence of competing endogenous cosubstrates of PHS peroxidase. | Diethylstilbestrol | pterin-4 alpha-carbinolamine dehydratase 1 | Homo sapiens |
| 7 | The results clearly indicate that SEMV cells catalyze PHS-dependent oxidation of DES as well as carrying out phase II metabolism in the absence of detectable monooxygenase activity. | Diethylstilbestrol | pterin-4 alpha-carbinolamine dehydratase 1 | Homo sapiens |