Pub. Date : 2009 Aug
PMID : 19294396
15 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Both all-trans retinoic acid and cytochrome P450 (CYP26) inhibitors affect the expression of vitamin A metabolizing enzymes and retinoid biomarkers in organotypic epidermis. | Vitamin A | cytochrome P450 family 26 subfamily A member 1 | Homo sapiens |
| 2 | Both all-trans retinoic acid and cytochrome P450 (CYP26) inhibitors affect the expression of vitamin A metabolizing enzymes and retinoid biomarkers in organotypic epidermis. | Retinoids | cytochrome P450 family 26 subfamily A member 1 | Homo sapiens |
| 3 | The biosynthesis of retinoic acid (RA) from retinol is controlled by several enzymes, e.g. dehydrogenases (RalDH2, RoDH-4) and retinol-esterifying enzyme (LRAT), whereas its degradation mainly involves CYP26 enzymes. | Tretinoin | cytochrome P450 family 26 subfamily A member 1 | Homo sapiens |
| 4 | The biosynthesis of retinoic acid (RA) from retinol is controlled by several enzymes, e.g. dehydrogenases (RalDH2, RoDH-4) and retinol-esterifying enzyme (LRAT), whereas its degradation mainly involves CYP26 enzymes. | Tretinoin | cytochrome P450 family 26 subfamily A member 1 | Homo sapiens |
| 5 | The biosynthesis of retinoic acid (RA) from retinol is controlled by several enzymes, e.g. dehydrogenases (RalDH2, RoDH-4) and retinol-esterifying enzyme (LRAT), whereas its degradation mainly involves CYP26 enzymes. | Vitamin A | cytochrome P450 family 26 subfamily A member 1 | Homo sapiens |
| 6 | Here, we examined the effects of RA and the CYP26 inhibitors, liarozole and talarozole, on retinoid metabolism and RA-regulated genes in organotypic epidermis. | Retinoids | cytochrome P450 family 26 subfamily A member 1 | Homo sapiens |
| 7 | RA induced the expression of CYP26 enzymes already after 8 h, whereas LRAT exhibited a later response and peaked at 48 h, indicating a feedback induction of retinol esterification. | Tretinoin | cytochrome P450 family 26 subfamily A member 1 | Homo sapiens |
| 8 | Cellular accumulation of exogenous [3H]RA was higher after talarozole than after liarozole, probably indicating a greater CYP26-inhibitory potency of the former drug. | Tritium | cytochrome P450 family 26 subfamily A member 1 | Homo sapiens |
| 9 | Cellular accumulation of exogenous [3H]RA was higher after talarozole than after liarozole, probably indicating a greater CYP26-inhibitory potency of the former drug. | Tretinoin | cytochrome P450 family 26 subfamily A member 1 | Homo sapiens |
| 10 | The present study shows that CYP26A1 expression is extremely sensitive to both exogenous RA and increased endogenous RA levels, i.e. due to CYP26 inhibition, and thus an excellent biomarker for retinoid signalling in organotypic epidermis. | Tretinoin | cytochrome P450 family 26 subfamily A member 1 | Homo sapiens |
| 11 | The present study shows that CYP26A1 expression is extremely sensitive to both exogenous RA and increased endogenous RA levels, i.e. due to CYP26 inhibition, and thus an excellent biomarker for retinoid signalling in organotypic epidermis. | Tretinoin | cytochrome P450 family 26 subfamily A member 1 | Homo sapiens |
| 12 | The present study shows that CYP26A1 expression is extremely sensitive to both exogenous RA and increased endogenous RA levels, i.e. due to CYP26 inhibition, and thus an excellent biomarker for retinoid signalling in organotypic epidermis. | Tretinoin | cytochrome P450 family 26 subfamily A member 1 | Homo sapiens |
| 13 | The present study shows that CYP26A1 expression is extremely sensitive to both exogenous RA and increased endogenous RA levels, i.e. due to CYP26 inhibition, and thus an excellent biomarker for retinoid signalling in organotypic epidermis. | Tretinoin | cytochrome P450 family 26 subfamily A member 1 | Homo sapiens |
| 14 | The present study shows that CYP26A1 expression is extremely sensitive to both exogenous RA and increased endogenous RA levels, i.e. due to CYP26 inhibition, and thus an excellent biomarker for retinoid signalling in organotypic epidermis. | Retinoids | cytochrome P450 family 26 subfamily A member 1 | Homo sapiens |
| 15 | The present study shows that CYP26A1 expression is extremely sensitive to both exogenous RA and increased endogenous RA levels, i.e. due to CYP26 inhibition, and thus an excellent biomarker for retinoid signalling in organotypic epidermis. | Retinoids | cytochrome P450 family 26 subfamily A member 1 | Homo sapiens |