Pub. Date : 2009 Mar
PMID : 19171200
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | All-trans retinoic acid (RA) levels are controlled by enzymes of the vitamin A metabolism (RDH16, RalDH2, and LRAT) and RA catabolism (CYP26 and CYP2S1). | 2-octenal | cytochrome P450 family 26 subfamily A member 1 | Homo sapiens |
| 2 | All-trans retinoic acid (RA) levels are controlled by enzymes of the vitamin A metabolism (RDH16, RalDH2, and LRAT) and RA catabolism (CYP26 and CYP2S1). | Tretinoin | cytochrome P450 family 26 subfamily A member 1 | Homo sapiens |
| 3 | All-trans retinoic acid (RA) levels are controlled by enzymes of the vitamin A metabolism (RDH16, RalDH2, and LRAT) and RA catabolism (CYP26 and CYP2S1). | Tretinoin | cytochrome P450 family 26 subfamily A member 1 | Homo sapiens |
| 4 | RA (1 microM) induced CYP26A1, CYP26B1, CYP2S1, CRABPII and LRAT mRNA. | Tretinoin | cytochrome P450 family 26 subfamily A member 1 | Homo sapiens |
| 5 | The CYP26 inhibitor talarozole altered CYP26A1 and LRAT mRNA expression in a similar way as RA, increased the cellular accumulation of [(3)H]RA, and induced a punctate CRABPII staining, also observed after siRNA knock-down of CYP26B1 (but not after RA exposure). | R 115866 | cytochrome P450 family 26 subfamily A member 1 | Homo sapiens |
| 6 | The CYP26 inhibitor talarozole altered CYP26A1 and LRAT mRNA expression in a similar way as RA, increased the cellular accumulation of [(3)H]RA, and induced a punctate CRABPII staining, also observed after siRNA knock-down of CYP26B1 (but not after RA exposure). | R 115866 | cytochrome P450 family 26 subfamily A member 1 | Homo sapiens |
| 7 | The CYP26 inhibitor talarozole altered CYP26A1 and LRAT mRNA expression in a similar way as RA, increased the cellular accumulation of [(3)H]RA, and induced a punctate CRABPII staining, also observed after siRNA knock-down of CYP26B1 (but not after RA exposure). | Tretinoin | cytochrome P450 family 26 subfamily A member 1 | Homo sapiens |
| 8 | Thus CYP26B1 appears essential for RA catabolism under physiological conditions, whereas CYP26A1 might play a greater role during RA excess. | Tretinoin | cytochrome P450 family 26 subfamily A member 1 | Homo sapiens |