Pub. Date : 1991 Aug 27
PMID : 1909177
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The amine-phosphate interaction also served to confirm that a quinazolin-4(3H)-one binds in the PNPase active sites like a purine substrate. | amine-phosphate | polyribonucleotide nucleotidyltransferase 1 | Homo sapiens |
| 2 | The amine-phosphate interaction also served to confirm that a quinazolin-4(3H)-one binds in the PNPase active sites like a purine substrate. | 4-hydroxyquinazoline | polyribonucleotide nucleotidyltransferase 1 | Homo sapiens |
| 3 | The amine-phosphate interaction also served to confirm that a quinazolin-4(3H)-one binds in the PNPase active sites like a purine substrate. | purine | polyribonucleotide nucleotidyltransferase 1 | Homo sapiens |
| 4 | From models of the PNPase active site it was possible to design quinazoline-based quinones that undergo a reductive-addition reaction with an active-site glutamate residue. | quinazoline-based quinones | polyribonucleotide nucleotidyltransferase 1 | Homo sapiens |
| 5 | From models of the PNPase active site it was possible to design quinazoline-based quinones that undergo a reductive-addition reaction with an active-site glutamate residue. | Glutamic Acid | polyribonucleotide nucleotidyltransferase 1 | Homo sapiens |
| 6 | The best inhibitor studied, 2-(chloromethyl)quinazoline-4,5,8(3H)-trione, rapidly inactivates PNPase by a first-order process with an inhibitor to enzyme stoichiometry of 150. | 2-(chloromethyl)quinazoline-4,5,8(3h)-trione | polyribonucleotide nucleotidyltransferase 1 | Homo sapiens |
| 7 | Thus, this inhibitor is designed to cross-link the PNPase active site by reductive addition followed by the generation of an alkylating quinone methide species. | quinone | polyribonucleotide nucleotidyltransferase 1 | Homo sapiens |