Pub. Date : 1991 Sep
PMID : 1897001
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Effect of allyl alcohol on xanthine dehydrogenase activity in the perfused rat liver. | allyl alcohol | xanthine dehydrogenase | Rattus norvegicus |
| 2 | A microassay for NAD(+)-dependent xanthine dehydrogenase, based on measuring the production of NADH fluorometrically under anaerobic conditions, was developed and used to examine the actions of allyl alcohol on this activity in periportal and pericentral regions of the liver lobule. | NAD | xanthine dehydrogenase | Rattus norvegicus |
| 3 | A microassay for NAD(+)-dependent xanthine dehydrogenase, based on measuring the production of NADH fluorometrically under anaerobic conditions, was developed and used to examine the actions of allyl alcohol on this activity in periportal and pericentral regions of the liver lobule. | Alcohols | xanthine dehydrogenase | Rattus norvegicus |
| 4 | Perfusion of the liver with allyl alcohol (350 microM) increased xanthine oxidase and decreased xanthine dehydrogenase in whole liver consistent with the hypothesis that allyl alcohol enhanced calcium-dependent proteolytic conversion of the NAD(+)-dependent to the O2-dependent form. | allyl alcohol | xanthine dehydrogenase | Rattus norvegicus |
| 5 | Perfusion of the liver with allyl alcohol (350 microM) increased xanthine oxidase and decreased xanthine dehydrogenase in whole liver consistent with the hypothesis that allyl alcohol enhanced calcium-dependent proteolytic conversion of the NAD(+)-dependent to the O2-dependent form. | allyl alcohol | xanthine dehydrogenase | Rattus norvegicus |
| 6 | Xanthine dehydrogenase was higher in pericentral than in periportal regions of the liver lobule and tended to decrease selectively in periportal zones of livers exposed to allyl alcohol. | Alcohols | xanthine dehydrogenase | Rattus norvegicus |
| 7 | These results are consistent with the idea that conversion of NAD(+)-dependent xanthine dehydrogenase to xanthine oxidase is involved in the zone-specific hepatotoxicity of allyl alcohol. | NAD | xanthine dehydrogenase | Rattus norvegicus |
| 8 | These results are consistent with the idea that conversion of NAD(+)-dependent xanthine dehydrogenase to xanthine oxidase is involved in the zone-specific hepatotoxicity of allyl alcohol. | allyl alcohol | xanthine dehydrogenase | Rattus norvegicus |