Pub. Date : 2009 Nov
PMID : 18953652
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | To clarify the molecular mechanism of these effects, we examined the expression of Ras/MAPK signaling pathway-related molecules in human and canine breast cancer cell lines, and found that the level of c-Raf-1 protein was reduced by 5, 10 and 20 mM of NaPA treatments, though Ras activation was maintained. | Acecainide | mitogen-activated protein kinase 1 | Canis lupus familiaris |
| 2 | To clarify the molecular mechanism of these effects, we examined the expression of Ras/MAPK signaling pathway-related molecules in human and canine breast cancer cell lines, and found that the level of c-Raf-1 protein was reduced by 5, 10 and 20 mM of NaPA treatments, though Ras activation was maintained. | Acecainide | TNF receptor associated factor 3 | Homo sapiens |
| 3 | Dephosphorylation of c-Raf-1 at Serine (Ser) 259, Ser 338, and Ser 621 were also seen in NaPA-treated cells. | Acecainide | TNF receptor associated factor 3 | Homo sapiens |
| 4 | Furthermore, expression of an epithelial marker, E-cadherin, was increased by NaPA treatment. | Acecainide | cadherin 1 | Canis lupus familiaris |
| 5 | These results suggest that one of the molecular targets of NaPA treatment was the reduction of c-Raf-1 protein, and that its reduction results in the decrease of malignant characteristics of tumor cells through blockage of the Ras/MAPK signaling pathway. | Acecainide | TNF receptor associated factor 3 | Homo sapiens |
| 6 | These results suggest that one of the molecular targets of NaPA treatment was the reduction of c-Raf-1 protein, and that its reduction results in the decrease of malignant characteristics of tumor cells through blockage of the Ras/MAPK signaling pathway. | Acecainide | mitogen-activated protein kinase 1 | Canis lupus familiaris |