Pub. Date : 2008 Nov 28
PMID : 18840609
26 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | B cell translocation gene 2 enhances susceptibility of HeLa cells to doxorubicin-induced oxidative damage. | Doxorubicin | BTG anti-proliferation factor 2 | Homo sapiens |
| 2 | In this study, the mechanism and role of BTG2 involved in the enhancement of doxorubicin (DOXO)-induced cell death were examined. | Doxorubicin | BTG anti-proliferation factor 2 | Homo sapiens |
| 3 | In this study, the mechanism and role of BTG2 involved in the enhancement of doxorubicin (DOXO)-induced cell death were examined. | Doxorubicin | BTG anti-proliferation factor 2 | Homo sapiens |
| 4 | Treatment of HeLa cells with DOXO revealed apoptotic phenomena, such as chromatin condensation and cleavage of poly(ADP-ribose) polymerase and lamin A/C with concomitant increase of BTG2/TIS21/PC3 expression. | Doxorubicin | BTG anti-proliferation factor 2 | Homo sapiens |
| 5 | Treatment of HeLa cells with DOXO revealed apoptotic phenomena, such as chromatin condensation and cleavage of poly(ADP-ribose) polymerase and lamin A/C with concomitant increase of BTG2/TIS21/PC3 expression. | Doxorubicin | BTG anti-proliferation factor 2 | Homo sapiens |
| 6 | Treatment of HeLa cells with DOXO revealed apoptotic phenomena, such as chromatin condensation and cleavage of poly(ADP-ribose) polymerase and lamin A/C with concomitant increase of BTG2/TIS21/PC3 expression. | Doxorubicin | BTG anti-proliferation factor 2 | Homo sapiens |
| 7 | Employing infections of Ad-TIS21 virus and lentivirus with short hairpin RNA to BTG2, the effect of BTG2/TIS21/PC3 on the DOXO-induced apoptosis of HeLa cells and liver cancer cells was evaluated. | Doxorubicin | BTG anti-proliferation factor 2 | Homo sapiens |
| 8 | Employing infections of Ad-TIS21 virus and lentivirus with short hairpin RNA to BTG2, the effect of BTG2/TIS21/PC3 on the DOXO-induced apoptosis of HeLa cells and liver cancer cells was evaluated. | Doxorubicin | BTG anti-proliferation factor 2 | Homo sapiens |
| 9 | Employing infections of Ad-TIS21 virus and lentivirus with short hairpin RNA to BTG2, the effect of BTG2/TIS21/PC3 on the DOXO-induced apoptosis of HeLa cells and liver cancer cells was evaluated. | Doxorubicin | BTG anti-proliferation factor 2 | Homo sapiens |
| 10 | Not only short hairpin RNA-BTG2 but also N-acetyl-L-cysteine significantly reduced the DOXO-induced HeLa cell death and generation of H2O2. | Doxorubicin | BTG anti-proliferation factor 2 | Homo sapiens |
| 11 | Not only short hairpin RNA-BTG2 but also N-acetyl-L-cysteine significantly reduced the DOXO-induced HeLa cell death and generation of H2O2. | Hydrogen Peroxide | BTG anti-proliferation factor 2 | Homo sapiens |
| 12 | Moreover, forced expression of BTG2/TIS21/PC3 using adenoviral vector augmented DOXO-induced cancer cell death concomitantly with increase of manganese-superoxide dismutase but not catalase, CuZnSOD, and glutathione peroxidase 1. | Doxorubicin | BTG anti-proliferation factor 2 | Homo sapiens |
| 13 | Moreover, forced expression of BTG2/TIS21/PC3 using adenoviral vector augmented DOXO-induced cancer cell death concomitantly with increase of manganese-superoxide dismutase but not catalase, CuZnSOD, and glutathione peroxidase 1. | Doxorubicin | BTG anti-proliferation factor 2 | Homo sapiens |
| 14 | Moreover, forced expression of BTG2/TIS21/PC3 using adenoviral vector augmented DOXO-induced cancer cell death concomitantly with increase of manganese-superoxide dismutase but not catalase, CuZnSOD, and glutathione peroxidase 1. | Doxorubicin | BTG anti-proliferation factor 2 | Homo sapiens |
| 15 | The increased apoptosis by forced expression of BTG2/TIS21/PC3 could be inhibited by N-acetyl-L-cysteine and polyethylene glycol-catalase. | Acetylcysteine | BTG anti-proliferation factor 2 | Homo sapiens |
| 16 | The increased apoptosis by forced expression of BTG2/TIS21/PC3 could be inhibited by N-acetyl-L-cysteine and polyethylene glycol-catalase. | Acetylcysteine | BTG anti-proliferation factor 2 | Homo sapiens |
| 17 | The increased apoptosis by forced expression of BTG2/TIS21/PC3 could be inhibited by N-acetyl-L-cysteine and polyethylene glycol-catalase. | Acetylcysteine | BTG anti-proliferation factor 2 | Homo sapiens |
| 18 | These results therefore suggest that BTG2/TIS21/PC3 works as an enhancer of DOXO-induced cell death via accumulation of H2O2 by up-regulating manganese-superoxide dismutase without any other antioxidant enzymes. | Doxorubicin | BTG anti-proliferation factor 2 | Homo sapiens |
| 19 | These results therefore suggest that BTG2/TIS21/PC3 works as an enhancer of DOXO-induced cell death via accumulation of H2O2 by up-regulating manganese-superoxide dismutase without any other antioxidant enzymes. | Doxorubicin | BTG anti-proliferation factor 2 | Homo sapiens |
| 20 | These results therefore suggest that BTG2/TIS21/PC3 works as an enhancer of DOXO-induced cell death via accumulation of H2O2 by up-regulating manganese-superoxide dismutase without any other antioxidant enzymes. | Doxorubicin | BTG anti-proliferation factor 2 | Homo sapiens |
| 21 | These results therefore suggest that BTG2/TIS21/PC3 works as an enhancer of DOXO-induced cell death via accumulation of H2O2 by up-regulating manganese-superoxide dismutase without any other antioxidant enzymes. | Hydrogen Peroxide | BTG anti-proliferation factor 2 | Homo sapiens |
| 22 | These results therefore suggest that BTG2/TIS21/PC3 works as an enhancer of DOXO-induced cell death via accumulation of H2O2 by up-regulating manganese-superoxide dismutase without any other antioxidant enzymes. | Hydrogen Peroxide | BTG anti-proliferation factor 2 | Homo sapiens |
| 23 | These results therefore suggest that BTG2/TIS21/PC3 works as an enhancer of DOXO-induced cell death via accumulation of H2O2 by up-regulating manganese-superoxide dismutase without any other antioxidant enzymes. | Hydrogen Peroxide | BTG anti-proliferation factor 2 | Homo sapiens |
| 24 | In summary, BTG2/TIS21/PC3 enhances cancer cell death by accumulating H2O2 via imbalance of the antioxidant enzymes in response to chemotherapy. | Hydrogen Peroxide | BTG anti-proliferation factor 2 | Homo sapiens |
| 25 | In summary, BTG2/TIS21/PC3 enhances cancer cell death by accumulating H2O2 via imbalance of the antioxidant enzymes in response to chemotherapy. | Hydrogen Peroxide | BTG anti-proliferation factor 2 | Homo sapiens |
| 26 | In summary, BTG2/TIS21/PC3 enhances cancer cell death by accumulating H2O2 via imbalance of the antioxidant enzymes in response to chemotherapy. | Hydrogen Peroxide | BTG anti-proliferation factor 2 | Homo sapiens |