Title : CHIP deletion reveals functional redundancy of E3 ligases in promoting degradation of both signaling proteins and expanded glutamine proteins.

Pub. Date : 2008 Dec 15

PMID : 18784277






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 CHIP (carboxy terminus of Hsc70-interacting protein) an E3 ubiquitin ligase that binds to Hsp70 and Hsp90, promotes degradation of several Hsp90-regulated signaling proteins and disease-causing proteins containing expanded glutamine tracts. Glutamine suppression of tumorigenicity 13 Mus musculus