Title : PX-478, an inhibitor of hypoxia-inducible factor-1alpha, enhances radiosensitivity of prostate carcinoma cells.

Pub. Date : 2008 Nov 15

PMID : 18729192






2 Functional Relationships(s)
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1 PX-478 (20 mumol/L) enhanced the radiosensitivity of PC3 cells irradiated under normoxic and hypoxic condition with enhancement factor (EF) 1.4 and 1.56, respectively. 2-amino-3-(4'-N,N-bis(2-chloroethyl)amino)phenylpropionic acid N-oxide BTG anti-proliferation factor 2 Homo sapiens
2 PX-478 induced S/G2M arrest in PC3 but not in DU 145 cells. 2-amino-3-(4'-N,N-bis(2-chloroethyl)amino)phenylpropionic acid N-oxide BTG anti-proliferation factor 2 Homo sapiens