Pub. Date : 2008 Nov
PMID : 18678612
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | OBJECTIVE: FFAR1/GPR40 is a G-protein-coupled receptor expressed predominantly in pancreatic islets mediating free fatty acid-induced insulin secretion. | Fatty Acids, Nonesterified | free fatty acid receptor 1 | Mus musculus |
| 2 | OBJECTIVE: FFAR1/GPR40 is a G-protein-coupled receptor expressed predominantly in pancreatic islets mediating free fatty acid-induced insulin secretion. | Fatty Acids, Nonesterified | free fatty acid receptor 1 | Mus musculus |
| 3 | A more recent report suggested that although FFAR1 was necessary for fatty acid-induced insulin secretion in vivo, deletion of FFAR1 did not protect pancreatic islets against fatty acid-induced islet dysfunction. | Fatty Acids | free fatty acid receptor 1 | Mus musculus |
| 4 | RESULTS: Insulin secretion was reduced by approximately 50% in Ffar1(-/-) mice, confirming that FFAR1 contributes significantly to fatty acid stimulation of insulin secretion in vivo. | Fatty Acids | free fatty acid receptor 1 | Mus musculus |
| 5 | RESULTS: Insulin secretion was reduced by approximately 50% in Ffar1(-/-) mice, confirming that FFAR1 contributes significantly to fatty acid stimulation of insulin secretion in vivo. | Fatty Acids | free fatty acid receptor 1 | Mus musculus |
| 6 | CONCLUSIONS: FFAR1 is required for normal insulin secretion in response to fatty acids; however, Ffar1(-/-) mice are not protected from high-fat diet-induced insulin resistance or hepatic steatosis. | Fatty Acids | free fatty acid receptor 1 | Mus musculus |