Title : Effects of growth hormone and insulin-like growth factor I on rabbit proximal convoluted tubule transport.

Pub. Date : 1991 Aug

PMID : 1864951






5 Functional Relationships(s)
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1 Addition of 5 x 10(-9) M and 5 x 10(-8) M IGF-I, but not 5 x 10(-10) M IGF-I, to the bathing solution resulted in an increase (12-15%) in phosphate transport, but no change in volume absorption or bicarbonate transport. Phosphates insulin-like growth factor I Oryctolagus cuniculus
2 Addition of 5 x 10(-9) M and 5 x 10(-8) M IGF-I, but not 5 x 10(-10) M IGF-I, to the bathing solution resulted in an increase (12-15%) in phosphate transport, but no change in volume absorption or bicarbonate transport. Bicarbonates insulin-like growth factor I Oryctolagus cuniculus
3 Addition of IGF-I to the luminal perfusate also stimulated phosphate transport. Phosphates insulin-like growth factor I Oryctolagus cuniculus
4 In the PCT, IGF-I stimulates phosphate transport specifically and acts via both basolateral and apical membranes. Phosphates insulin-like growth factor I Oryctolagus cuniculus
5 These data are consistent with IGF-I mediating the in vivo stimulation of phosphate transport by growth hormone. Phosphates insulin-like growth factor I Oryctolagus cuniculus