Title : Calcitonin receptor plays a physiological role to protect against hypercalcemia in mice.

Pub. Date : 2008 Aug

PMID : 18627265






5 Functional Relationships(s)
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1 Therefore, to elucidate the physiological role of the CTR in calcium and bone metabolism, we generated a viable global CTR knockout (KO) mouse model using the Cre/loxP system, in which the CTR is globally deleted by >94% but <100%. Calcium calcitonin receptor Mus musculus
2 Global CTRKOs displayed normal serum ultrafiltrable calcium levels and a mild increase in bone formation in males, showing that the CTR plays a modest physiological role in the regulation of bone and calcium homeostasis in the basal state in mice. Calcium calcitonin receptor Mus musculus
3 Global CTRKOs displayed normal serum ultrafiltrable calcium levels and a mild increase in bone formation in males, showing that the CTR plays a modest physiological role in the regulation of bone and calcium homeostasis in the basal state in mice. Calcium calcitonin receptor Mus musculus
4 These data provide strong evidence for a biological role of the CTR in regulating calcium homeostasis in states of calcium stress. Calcium calcitonin receptor Mus musculus
5 These data provide strong evidence for a biological role of the CTR in regulating calcium homeostasis in states of calcium stress. Calcium calcitonin receptor Mus musculus