Title : CD98 activation increases surface expression and clusteringof beta1 integrins in MCF-7 cells through FAK/Src- and cytoskeleton-independent mechanisms.

Pub. Date : 2008 Jun 30

PMID : 18587263






6 Functional Relationships(s)
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Protein Name
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1 CD98, a disulfide-linked 125-kDa heterodimeric type II transmembrane glycoprotein, regulates beta1 integrin- mediated cell adhesion. Disulfides solute carrier family 3 member 2 Homo sapiens
2 In addition, phalloidin or cytochalasin D inhibited CD98-mediated induction of cell-ECM adhesion, but not surface expression and clustering of beta1 integrins. Phalloidine solute carrier family 3 member 2 Homo sapiens
3 In addition, phalloidin or cytochalasin D inhibited CD98-mediated induction of cell-ECM adhesion, but not surface expression and clustering of beta1 integrins. Cytochalasin D solute carrier family 3 member 2 Homo sapiens
4 The inhibitory effects of PP2, cytochalasin D or phalloidin on CD98-stimulated cell adhesion were diminished by pretreatment of cells with Mn2+, which is shown to induce conformational change of integrins. Cytochalasin D solute carrier family 3 member 2 Homo sapiens
5 The inhibitory effects of PP2, cytochalasin D or phalloidin on CD98-stimulated cell adhesion were diminished by pretreatment of cells with Mn2+, which is shown to induce conformational change of integrins. Phalloidine solute carrier family 3 member 2 Homo sapiens
6 The inhibitory effects of PP2, cytochalasin D or phalloidin on CD98-stimulated cell adhesion were diminished by pretreatment of cells with Mn2+, which is shown to induce conformational change of integrins. Manganese(2+) solute carrier family 3 member 2 Homo sapiens