Pub. Date : 2008 Jul
PMID : 18575781
13 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | H2O2 induced ubiquitination of RCAN1 at the same concentrations as those causing a decrease in RCAN1 in HEK293T cells. | Hydrogen Peroxide | regulator of calcineurin 1 | Homo sapiens |
| 2 | H2O2 induced ubiquitination of RCAN1 at the same concentrations as those causing a decrease in RCAN1 in HEK293T cells. | Hydrogen Peroxide | regulator of calcineurin 1 | Homo sapiens |
| 3 | beta-TrCP, the F-box protein component of SCF ubiquitin ligase, interacted with RCAN1 in response to H2O2 stimulation. | Hydrogen Peroxide | regulator of calcineurin 1 | Homo sapiens |
| 4 | In vitro ubiquitination assay showed that SCFbeta-TrCP but not SCFFBW4 increased ubiquitination of RCAN1, dependent on H2O2 stimulation. | Hydrogen Peroxide | regulator of calcineurin 1 | Homo sapiens |
| 5 | In addition, knockdown of beta-TrCP by siRNA abolished the H2O2-induced decrease in RCAN1 in HEK293T cells. | Hydrogen Peroxide | regulator of calcineurin 1 | Homo sapiens |
| 6 | We further examined whether RCAN1 undergoes ubiquitination by H2O2 in primary neurons, similarly to that in HEK293T cells. | Hydrogen Peroxide | regulator of calcineurin 1 | Homo sapiens |
| 7 | An H2O2-induced decrease in RCAN1 was exhibited also in hippocampal and cortical neurons. | Hydrogen Peroxide | regulator of calcineurin 1 | Homo sapiens |
| 8 | Ubiquitination of RCAN1 was induced by 500 muM H2O2, the concentration at which H2O2 induced a decrease in RCAN1 in primary neurons. | Hydrogen Peroxide | regulator of calcineurin 1 | Homo sapiens |
| 9 | Ubiquitination of RCAN1 was induced by 500 muM H2O2, the concentration at which H2O2 induced a decrease in RCAN1 in primary neurons. | Hydrogen Peroxide | regulator of calcineurin 1 | Homo sapiens |
| 10 | Ubiquitination of RCAN1 was induced by 500 muM H2O2, the concentration at which H2O2 induced a decrease in RCAN1 in primary neurons. | Hydrogen Peroxide | regulator of calcineurin 1 | Homo sapiens |
| 11 | Ubiquitination of RCAN1 was induced by 500 muM H2O2, the concentration at which H2O2 induced a decrease in RCAN1 in primary neurons. | Hydrogen Peroxide | regulator of calcineurin 1 | Homo sapiens |
| 12 | These results suggest that H2O2 induces SCF beta-TrCP-mediated ubiquitination of RCAN1, leading to a decrease in the protein level of RCAN1. | Hydrogen Peroxide | regulator of calcineurin 1 | Homo sapiens |
| 13 | These results suggest that H2O2 induces SCF beta-TrCP-mediated ubiquitination of RCAN1, leading to a decrease in the protein level of RCAN1. | Hydrogen Peroxide | regulator of calcineurin 1 | Homo sapiens |