Pub. Date : 2008 Sep
PMID : 18559658
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | OBJECTIVE: The G-protein-coupled receptor GPR40 is expressed in pancreatic beta-cells and is activated by long-chain fatty acids. | long-chain fatty acids | free fatty acid receptor 1 | Mus musculus |
| 2 | Gene deletion studies have shown that GPR40 mediates, at least in part, fatty acid-amplification of glucose-induced insulin secretion (GSIS) but is not implicated in GSIS itself. | Fatty Acids | free fatty acid receptor 1 | Mus musculus |
| 3 | CONCLUSIONS: GPR40 plays a role not only in fatty acid modulation of insulin secretion, but also in GSIS after high-fat feeding. | Fatty Acids | free fatty acid receptor 1 | Mus musculus |