Title : Diet-induced alteration in the activity of plasma lipid transfer protein in normolipidemic human subjects.

Pub. Date : 1991 Apr

PMID : 1854368






9 Functional Relationships(s)
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1 Studies were performed to investigate the effect of diets rich in oleic or linoleic acids on the activity of plasma cholesteryl ester transfer protein (CETP) in normolipidemic subjects. oleic cholesteryl ester transfer protein Homo sapiens
2 Studies were performed to investigate the effect of diets rich in oleic or linoleic acids on the activity of plasma cholesteryl ester transfer protein (CETP) in normolipidemic subjects. oleic cholesteryl ester transfer protein Homo sapiens
3 Studies were performed to investigate the effect of diets rich in oleic or linoleic acids on the activity of plasma cholesteryl ester transfer protein (CETP) in normolipidemic subjects. Linoleic Acids cholesteryl ester transfer protein Homo sapiens
4 Studies were performed to investigate the effect of diets rich in oleic or linoleic acids on the activity of plasma cholesteryl ester transfer protein (CETP) in normolipidemic subjects. Linoleic Acids cholesteryl ester transfer protein Homo sapiens
5 The activity of CETP was measured, using a method independent of endogenous plasma lipoproteins, as the rate of exchange of radioactive cholesteryl oleate between labelled LDL and unlabelled HDL. cholesteryl oleate cholesteryl ester transfer protein Homo sapiens
6 The "mono-diet" induced a statistically significant decrease in CETP activity (from 115 +/- 20 to 102 +/- 19 units/ml plasma, P less than 0.01), while the small decrease on the "poly-diet" (from 111 +/- 23 to 107 +/- 22 units/ml plasma) did not reach significancy. mono-diet cholesteryl ester transfer protein Homo sapiens
7 The percentual decrease in CETP activity induced by the "mono-diet" was higher than that induced by the "poly-diet" as was also found for the decrease in LDL cholesterol. Cholesterol cholesteryl ester transfer protein Homo sapiens
8 In both diet groups a positive correlation was found between changes in CETP activity and changes in plasma total or (VLDL + LDL) cholesterol. Cholesterol cholesteryl ester transfer protein Homo sapiens
9 The results suggest that high levels of dietary monounsaturated fatty acids may result in decreased plasma CETP activity, as well as LDL cholesterol levels. Fatty Acids, Monounsaturated cholesteryl ester transfer protein Homo sapiens