Pub. Date : 1991 May 5
PMID : 1850741
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Using soybean lipoxygenase-1 as a model, we have shown that two classes of lipoxygenase inhibitors currently in development as potential antiinflammatory agents obtain a significant amount of their potency by reducing the lipoxygenase active-site iron from the active ferric state to the inactive ferrous state. | Iron | linoleate 9S-lipoxygenase-4 | Glycine max |
| 2 | Using soybean lipoxygenase-1 as a model, we have shown that two classes of lipoxygenase inhibitors currently in development as potential antiinflammatory agents obtain a significant amount of their potency by reducing the lipoxygenase active-site iron from the active ferric state to the inactive ferrous state. | Iron | linoleate 9S-lipoxygenase-4 | Glycine max |
| 3 | This brings to (at least) five the number of classes of lipoxygenase inhibitors that are capable of reducing the active-site ferric ion and suggests the generality of this approach in the rational design of lipoxygenase inhibitors. | Ferric enterobactin ion | linoleate 9S-lipoxygenase-4 | Glycine max |
| 4 | This brings to (at least) five the number of classes of lipoxygenase inhibitors that are capable of reducing the active-site ferric ion and suggests the generality of this approach in the rational design of lipoxygenase inhibitors. | Ferric enterobactin ion | linoleate 9S-lipoxygenase-4 | Glycine max |