Title : Administration of a synthetic TLR4 agonist protects mice from pneumonic tularemia.

Pub. Date : 2008 Jun 1

PMID : 18490759






2 Functional Relationships(s)
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1 Mice treated with AGPs before and after inhalation of Francisella novicida exhibited augmented cytokine and inflammatory responses to infection; reduced bacterial replication in lung, liver, and spleen; and increased survival, whereas all PBS-treated control mice died within 4 days of infection, all AGP-treated mice showed prolonged time-to-death, and 30-60% of AGP-treated mice survived. Lead alkylglycerone phosphate synthase Mus musculus
2 Mice treated with AGPs before and after inhalation of Francisella novicida exhibited augmented cytokine and inflammatory responses to infection; reduced bacterial replication in lung, liver, and spleen; and increased survival, whereas all PBS-treated control mice died within 4 days of infection, all AGP-treated mice showed prolonged time-to-death, and 30-60% of AGP-treated mice survived. agp alkylglycerone phosphate synthase Mus musculus