Title : Dose-dependent increases in metallothionein synthesis in the lung and liver of paraquat-treated rats.

Pub. Date : 1991 Jan

PMID : 1846247






7 Functional Relationships(s)
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1 Dose-dependent changes in the concentration of metallothionein-1 (MT-1) in rat tissues were determined following subcutaneous administration of paraquat (PQ), a superoxide radical-generating agent. Paraquat metallothionein 1 Rattus norvegicus
2 Dose-dependent changes in the concentration of metallothionein-1 (MT-1) in rat tissues were determined following subcutaneous administration of paraquat (PQ), a superoxide radical-generating agent. Paraquat metallothionein 1 Rattus norvegicus
3 Dose-dependent changes in the concentration of metallothionein-1 (MT-1) in rat tissues were determined following subcutaneous administration of paraquat (PQ), a superoxide radical-generating agent. Paraquat metallothionein 1 Rattus norvegicus
4 Dose-dependent changes in the concentration of metallothionein-1 (MT-1) in rat tissues were determined following subcutaneous administration of paraquat (PQ), a superoxide radical-generating agent. Paraquat metallothionein 1 Rattus norvegicus
5 MT-1 concentrations in the lung increased linearly with PQ dose. Paraquat metallothionein 1 Rattus norvegicus
6 PQ-induced MT-1 synthesis may reflect de novo protein synthesis, since the increase in MT-1 in the liver was reduced by pretreatment of the rats with actinomycin D. Paraquat metallothionein 1 Rattus norvegicus
7 PQ-induced MT-1 synthesis may reflect de novo protein synthesis, since the increase in MT-1 in the liver was reduced by pretreatment of the rats with actinomycin D. Paraquat metallothionein 1 Rattus norvegicus