Pub. Date : 2008 Jun 27
PMID : 18458078
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Tip60 is regulated by circadian transcription factor clock and is involved in cisplatin resistance. | Cisplatin | lysine acetyltransferase 5 | Homo sapiens |
| 2 | We found that Tip60 is overexpressed in cisplatin-resistant cells. | Cisplatin | lysine acetyltransferase 5 | Homo sapiens |
| 3 | Knockdown of Tip60 expression rendered cells sensitive to cisplatin but not to oxaliplatin, vincristine, and etoposide. | Cisplatin | lysine acetyltransferase 5 | Homo sapiens |
| 4 | Tip60 expression is significantly correlated with cisplatin sensitivity in human lung cancer cell lines. | Cisplatin | lysine acetyltransferase 5 | Homo sapiens |
| 5 | Our data show that HAT gene expression is required for cisplatin resistance and suggest that Clock and Tip60 regulate not only transcription, but also DNA repair, through periodic histone acetylation. | Cisplatin | lysine acetyltransferase 5 | Homo sapiens |