Title : Improved resistance to oxidative stress by a loss-of-function mutation in the Arabidopsis UGT71C1 gene.

Pub. Date : 2008 May 31

PMID : 18443422






12 Functional Relationships(s)
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1 Previously, UGT71C1 was shown to glycosylate the 3-OH of hydroxycinnamates and flavonoids in vitro. hydroxycinnamates UDP-glucosyl transferase 71C1 Arabidopsis thaliana
2 Previously, UGT71C1 was shown to glycosylate the 3-OH of hydroxycinnamates and flavonoids in vitro. Flavonoids UDP-glucosyl transferase 71C1 Arabidopsis thaliana
3 Interestingly, upon treatment with methyl viologen (MV, paraquat), ugt71c1-1 plants displayed enhanced resistance to oxidative stress, and ROS scavenging activity was higher than normal. Paraquat UDP-glucosyl transferase 71C1 Arabidopsis thaliana
4 Metabolite profiling revealed that the levels of two major glycosides of quercetin and kaempferol were reduced in ugt71c1-1 plants. Glycosides UDP-glucosyl transferase 71C1 Arabidopsis thaliana
5 Metabolite profiling revealed that the levels of two major glycosides of quercetin and kaempferol were reduced in ugt71c1-1 plants. Quercetin UDP-glucosyl transferase 71C1 Arabidopsis thaliana
6 Metabolite profiling revealed that the levels of two major glycosides of quercetin and kaempferol were reduced in ugt71c1-1 plants. kaempferol UDP-glucosyl transferase 71C1 Arabidopsis thaliana
7 In addition, when exposed to MV-induced oxidative stress, eight representative ROS response genes were expressed at lower levels in ugt71c1-1 plants, indicating that ugt71c1-1 probably has higher non-enzymatic antioxidant activity. Paraquat UDP-glucosyl transferase 71C1 Arabidopsis thaliana
8 In addition, when exposed to MV-induced oxidative stress, eight representative ROS response genes were expressed at lower levels in ugt71c1-1 plants, indicating that ugt71c1-1 probably has higher non-enzymatic antioxidant activity. Paraquat UDP-glucosyl transferase 71C1 Arabidopsis thaliana
9 In addition, when exposed to MV-induced oxidative stress, eight representative ROS response genes were expressed at lower levels in ugt71c1-1 plants, indicating that ugt71c1-1 probably has higher non-enzymatic antioxidant activity. ros UDP-glucosyl transferase 71C1 Arabidopsis thaliana
10 In addition, when exposed to MV-induced oxidative stress, eight representative ROS response genes were expressed at lower levels in ugt71c1-1 plants, indicating that ugt71c1-1 probably has higher non-enzymatic antioxidant activity. ros UDP-glucosyl transferase 71C1 Arabidopsis thaliana
11 Taken together, our results indicate that ugt71c1-1 has increased resistance to oxidative stress, suggesting that UGT71C1 plays a role in some glycosylation pathways affecting secondary metabolites such as flavonoids in response to oxidative stress. Flavonoids UDP-glucosyl transferase 71C1 Arabidopsis thaliana
12 Taken together, our results indicate that ugt71c1-1 has increased resistance to oxidative stress, suggesting that UGT71C1 plays a role in some glycosylation pathways affecting secondary metabolites such as flavonoids in response to oxidative stress. Flavonoids UDP-glucosyl transferase 71C1 Arabidopsis thaliana