Pub. Date : 2008 Apr
PMID : 18379071
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In this study, we examined the modulatory effect of chloroquine on the functional activation of beta1-integrins (CD29) using CD29- and CD98 (a functional regulator of CD29)-mediated U937 cell-cell adhesion, comparing macrophage functions and T cell proliferation. | Chloroquine | solute carrier family 3 member 2 | Homo sapiens |
| 2 | Chloroquine effectively suppressed U937 cell-cell adhesion mediated by CD29 and CD98, in a protein kinase (PK) C, PKA, protein tyrosine kinase (PTK), extracellular signal-regulated kinase (ERK) and actin cytoskeleton-independent manner. | Chloroquine | solute carrier family 3 member 2 | Homo sapiens |
| 3 | Other lysomotropic agents (monesin, methylamine and ammonium chloride) also significantly diminished both CD29- and CD98-mediated cell-cell adhesion, indicating that lysomotropic character may play a critical role in regulating beta1-integrin functions. | monesin | solute carrier family 3 member 2 | Homo sapiens |
| 4 | Other lysomotropic agents (monesin, methylamine and ammonium chloride) also significantly diminished both CD29- and CD98-mediated cell-cell adhesion, indicating that lysomotropic character may play a critical role in regulating beta1-integrin functions. | methylamine | solute carrier family 3 member 2 | Homo sapiens |
| 5 | Other lysomotropic agents (monesin, methylamine and ammonium chloride) also significantly diminished both CD29- and CD98-mediated cell-cell adhesion, indicating that lysomotropic character may play a critical role in regulating beta1-integrin functions. | Ammonium Chloride | solute carrier family 3 member 2 | Homo sapiens |