Title : Integration of global signaling pathways, cAMP-PKA, MAPK and TOR in the regulation of FLO11.

Pub. Date : 2008 Feb 27

PMID : 18301741






6 Functional Relationships(s)
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1 Integration of global signaling pathways, cAMP-PKA, MAPK and TOR in the regulation of FLO11. Cyclic AMP Flo11p Saccharomyces cerevisiae S288C
2 This transition is governed by a complex network of signaling pathways, namely cAMP-PKA, MAPK and TOR, which controls the transcriptional activation of FLO11, a flocculin gene that encodes a cell wall protein. Cyclic AMP Flo11p Saccharomyces cerevisiae S288C
3 Our experiments demonstrate that the steady state expression of FLO11 was bistable over a range of inducing ammonium sulphate concentration based on the preculturing condition. Ammonium Sulfate Flo11p Saccharomyces cerevisiae S288C
4 Negative feedback on TOR pathway function to restrict the expression of FLO11 under nitrogen starved condition and also with re-addition of nitrogen to starved cells. Toremifene Flo11p Saccharomyces cerevisiae S288C
5 Negative feedback on TOR pathway function to restrict the expression of FLO11 under nitrogen starved condition and also with re-addition of nitrogen to starved cells. Nitrogen Flo11p Saccharomyces cerevisiae S288C
6 In general, we show that these global signaling pathways respond with specific sensitivity to regulate the expression of FLO11 under nitrogen limitation. Nitrogen Flo11p Saccharomyces cerevisiae S288C