Title : Concerted inhibition of NADP+-specific isocitrate dehydrogenase by oxalacetate and glyoxylate. I. Oxalomalate formation and stability, and nature of the enzyme inhibition.

Pub. Date : 1977 Jul 8

PMID : 18195






1 Functional Relationships(s)
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1 Oxalacetate and glyoxylate are each weak inhibitors of NADP+-specific isocitrate dehydrogenase (threo-DS-isocitrate:NADP+ oxidoreductase (decarboxylating), EC 1.1.1.42)9 Together, however, they act in a concerted manner and strongly inhibit the enzyme. glyoxylic acid hydroxysteroid 17-beta dehydrogenase 6 Homo sapiens