Pub. Date : 2008 May 8
PMID : 18059332
10 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | A novel role for the retinoic acid-catabolizing enzyme CYP26A1 in Barrett"s associated adenocarcinoma. | Tretinoin | cytochrome P450 family 26 subfamily A member 1 | Homo sapiens |
| 2 | Vitamin A deficiency is associated with carcinogenesis, and upregulation of CYP26A1, a major retinoic acid (RA)-catabolizing enzyme, has recently been shown in cancer. | Tretinoin | cytochrome P450 family 26 subfamily A member 1 | Homo sapiens |
| 3 | Vitamin A deficiency is associated with carcinogenesis, and upregulation of CYP26A1, a major retinoic acid (RA)-catabolizing enzyme, has recently been shown in cancer. | Tretinoin | cytochrome P450 family 26 subfamily A member 1 | Homo sapiens |
| 4 | CYP26A1 was stably overexpressed in GihTERT cells, which were evaluated for gene-expression changes (pathway array and quantitative RT-PCR), cellular proliferation (cytometric DNA profile and colorimetric assay) and invasion (in vitro matrigel assay) with or without the CYP inhibitor ketaconazole. | ketaconazole | cytochrome P450 family 26 subfamily A member 1 | Homo sapiens |
| 5 | RA levels decreased progressively with the degree of dysplasia (P<0.05) and were inversely correlated with CYP26A1 gene levels and activity (P<0.01). | Tretinoin | cytochrome P450 family 26 subfamily A member 1 | Homo sapiens |
| 6 | CYP26A1 expression was increased synergistically by RA and lithocholic acid (P<0.05). | Tretinoin | cytochrome P450 family 26 subfamily A member 1 | Homo sapiens |
| 7 | CYP26A1 expression was increased synergistically by RA and lithocholic acid (P<0.05). | Lithocholic Acid | cytochrome P450 family 26 subfamily A member 1 | Homo sapiens |
| 8 | CYP26A1 expression was increased synergistically by RA and lithocholic acid (P<0.05). | p< | cytochrome P450 family 26 subfamily A member 1 | Homo sapiens |
| 9 | Functional effects of CYP26A1 overexpression were increased proliferation (P<0.01) and invasion in vitro (P<0.01), which were inhibited by ketaconazole. | ketaconazole | cytochrome P450 family 26 subfamily A member 1 | Homo sapiens |
| 10 | Overexpression of CYP26A1 causes intracellular RA depletion and drives the cell into a highly proliferative and invasive state with induction of other known oncogenes. | Tretinoin | cytochrome P450 family 26 subfamily A member 1 | Homo sapiens |