Title : The role of murine tumour models and their acquired platinum-resistant counterparts in the evaluation of novel platinum antitumour agents: a cautionary note.

Pub. Date : 1991 Sep

PMID : 1793720






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Two murine tumour models, the L1210 leukaemia and the ADJ/PC6 plasmacytoma, have featured prominently in the preclinical development of platinum drugs. Platinum proprotein convertase subtilisin/kexin type 5 Mus musculus
2 Mindful of the unequivocal need to discover new platinum-based drugs exhibiting activity in cisplatin/carboplatin refractory and relapsed cancers, and to devise clinically-predictive screening models, we have generated resistance in vivo in the ADJ/PC6 plasmacytoma to cisplatin (19- to 21-fold), to carboplatin (25-fold), iproplatin (greater than 14-fold) and tetraplatin (10-fold). Platinum proprotein convertase subtilisin/kexin type 5 Mus musculus