Pub. Date : 1991 Sep
PMID : 1793720
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | Two murine tumour models, the L1210 leukaemia and the ADJ/PC6 plasmacytoma, have featured prominently in the preclinical development of platinum drugs. | Platinum | proprotein convertase subtilisin/kexin type 5 | Mus musculus |
2 | Mindful of the unequivocal need to discover new platinum-based drugs exhibiting activity in cisplatin/carboplatin refractory and relapsed cancers, and to devise clinically-predictive screening models, we have generated resistance in vivo in the ADJ/PC6 plasmacytoma to cisplatin (19- to 21-fold), to carboplatin (25-fold), iproplatin (greater than 14-fold) and tetraplatin (10-fold). | Platinum | proprotein convertase subtilisin/kexin type 5 | Mus musculus |