Title : Dendrimer-based BH3 conjugate that targets human carcinoma cells.

Pub. Date : 2007 Oct

PMID : 17877400






2 Functional Relationships(s)
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1 Our previous studies have demonstrated the efficacy of generation 5 poly(amidoamine) dendrimers (G5-PAMAM) as a platform for the targeted delivery of chemotherapeutics. poly(amidoamine) dendrimers G-patch domain and ankyrin repeats 1 Homo sapiens
2 In order to specifically target BH3 peptides to cancer cells, we synthesized a trifunctional, G5-PAMAM-based nanodevice to which folic acid was conjugated as a targeting agent, along with fluorescein isothiocyanate as the reporter agent and BH3 peptides that were used to induce apoptosis. Folic Acid G-patch domain and ankyrin repeats 1 Homo sapiens